XanGo & The Mangosteen! History Tells All! Facts Not Fiction!

[Edith E. Sperl]

Xanthone Measurement
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Overview

As awareness and consumption of the mangosteen has increased worldwide, so has the need to better understand the fruit’s most prominent phytonutrient, xanthones. The mangosteen fruit has nature’s most concentrated source of xanthones, a family of vigorous antioxidants.

To establish a rapid, dependable approach for identifying xanthones in their naturally occurring state, researchers were asked to develop a credible, easily duplicable analytical method for testing and measuring xanthones in the rind of the mangosteen fruit, Garcinia mangostana. The whole mangosteen fruit rind was chosen as the standard because its response factor is similar to many of the naturally occurring xanthones and is nature’s most abundant source of xanthones.

The peer-reviewed, single lab validated high performance liquid chromatography (HPLC) analysis of selected xanthones in mangosteen fruit study was published in the June 2007 issue of the Journal of Separation Science. The study utilized AOAC protocols. AOAC International is a not-for-profit scientific association that sets standard methods which allow consumers to have confidence in analytical results obtained from scientific analysis.

Researchers

Edward Walker, Ph.D., Department of Chemistry, Weber State University, created the analytical method for identifying and extracting xanthones from the mangosteen fruit. During Walker's 25-year tenure at WSU, he has published numerous scientific articles ranging from the identification of new sensory transduction components in living cells to methods of analysis for natural products.

Research lab, ChromaDex, LLC, developed the standards in accordance with AOAC protocol to quantify xanthones through comparison measurement of detector response factors of individual xanthones. ChromaDex was established in 1999 and has become the market leader in the creation and supply of botanical reference standards along with related phytochemical products and services.

Methods (developed in accordance with AOAC protocol)

Xanthone extraction and identification

An 80:20 acetone/water mixture was used to extract the xanthones from dried, ground whole mangosteen fruit rind. A total of six xanthones were purified by preparative HPLC, utilizing the same solvent system and UV detection as for the analytical method. Each compound has unique UV absorption spectra that allows for easy identification of the xanthone found naturally in the mangosteen fruit.

Xanthone analysis and quantification

The same chromatographic analysis used for extraction and identification was used to quantify xanthones through comparison measurement of detector response factors of individual xanthones.

Results

The study, published in the June 2007 issue of the Journal of Separation Science, establishes a credible scientific method for testing and measuring xanthones. Six specific xanthones have been identified, and their relative response factors determined. Although additional xanthones are in the process of being identified and measured, this research ensures a more consistent and reliable marketing of mangosteen products to consumers relative to xanthone content claims.

Xanthone Bioavailability (Preliminary)
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Study Overview

A pre-clinical, preliminary 28-day study of XanGo® Juice identified the bioavailability of xanthones to determine how many xanthones the body actually absorbs and the pathway they travel. A validated xanthone analysis method was used to measure the quantities of the alpha-mangostin xanthone found in blood plasma.

Researchers

Michael W. Pugh, B.S., XanGo research and development senior manager, Michael Pugh has more than 15 years experience in the natural products industry and is currently head of Research & Development for XanGo, LLC. In this capacity, Pugh has implemented safety studies, initiated analytical work and validation, established pharmacokinetics and oversees all clinical work.

Charles River Laboratories Charles River Laboratories is a pre-clinical lab that was established in 1947. It is world renowned for its research models in safety, pharmacokinetics, and in-vitro work. It employs 7,500 employees, including 500 researchers that include PhDs, MDs and DVMs.

Methods

The validated plasma method used LC-MS/MS technique to identify and quantify the amounts of alpha-mangostin in the plasma. This new analysis can quantify levels as low as 1 nanogram per ml (ng/ml).

Results

The preliminary research demonstrates that the body absorbs xanthones in low dosages and that very high levels of xanthone consumption actually result in decreased absorption efficiency. In addition, preliminary results showed long-term daily consumption of XanGo Juice increases the levels of xanthones in the blood.

More specifically, the study showed the following regarding alpha-mangostin:

In approximately 3.5 hours, the xanthone has been absorbed during digestion.
Females have a more efficient absorption rate than males.
Long-term consumption of XanGo Juice causes a blood loading effect.
Alpha-mangostin is absorbed they way nature intended, at very low doses of consumption, such as the amount contained in XanGo Juice.
At very high levels, the absorption efficiency of the xanthone decreases.
This study allows for a solid foundation for future clinical trials. Also, these preliminary findings show artificially inflating a product with xanthone extracts does not add any value.

Terms

Mangosteen fruit (Garcinia mangostana)

An evergreen tree native to Southeast Asia that has leathery leaves and large edible fruit. Latin name: Garcinia mangostana 2. The fruit with a hard, reddish-brown rind and sweet, juicy pulp produced by the mangosteen tree. Also known as the “Queen of Fruits.”

The whole mangosteen fruit, nature's most abundant source, contains 39 different xanthones (as found in XanGo Juice).

Xanthones

C13H8O2 a unique class of biologically active compounds possessing numerous bioactive capabilities, such as antioxidant properties. They are a unique class of phytonutrients. Xanthones—found in the whole mangosteen fruit—may help maintain intestinal health, strengthen the immune system, neutralize free radicals, help support cartilage and joint function and promote a healthy seasonal respiratory system.

Phytonutrients

Any of various bioactive chemical compounds found in plants, such as antioxidants, considered to be beneficial to human health. Also referred to as phytochemical.

Pericarp/Rind

The walls of a ripened fruit, sometimes consisting of three layers, the epicarp, mesocarp and endocarp. Also referred to as the rind.

Antioxidant

Any substance that inhibits the destructive effects of oxidation. Antioxidants deactivate free radicals before they have a chance to harm your body.


History & Tradition
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Having originated in Southeast Asia, the whole mangosteen fruit has been revered for its taste, but also for its healing properties. Historically, the whole fruit was used to treat people both topically and internally. This was done by either grinding the rind down and applying it directly to the skin or steeping it in water overnight and then drinking the resulting mangosteen tea. It has been used to restore intestinal health for centuries, as well as treat other infections.

Documented internal and external use:

In the book Fruits of Warm Climates, Dr. Morton calls particular attention to the importance of mangosteen rind in traditional preparations. She recorded that the mangosteen rind was sliced, dried, powdered and then administered. Often times it was first made into an ointment and then applied topically on skin disorders. Additionally, she states “the rind decoction is applied externally as an astringent lotion.” Dr. Morton also makes mention of internal uses of the rind. “A portion of the rind is steeped in water overnight and the infusion given as a remedy.”

On May 26, 1885 The Illustrated London News reported that “Dr Garcin says the mangosteen is the only fruit which sick people are allowed to eat unsparingly; it is given with safety in almost every disorder.”


Modern Science
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Modern science is only now beginning to understand and explain why the rind of the mangosteen fruit has been so revered for centuries. However, we know this: to benefit from the complete power and nutritional impact of the mangosteen fruit, it should be consumed just as it has been for more than a thousand years—in its whole fruit form.

As early as 1933, studies were conducted to compare the whole fruit to single compound extracts taken from the rind. In 1933, Caius and Mhaskar found that the whole fruit offered more than 60% success rates in boosting and restoring intestinal health. In short, consumption of the whole mangosteen rind delivers benefits far superior to chemical extracts from that same rind.

On-going research continues to find valuable properties and several active phytochemicals have already been identified in the fruit, including:

39 different xanthones – These powerful phytonutrients demonstrate unique and valuable health properties.
catechins – The mangosteen rind has been shown to have the same level of this active ingredient as found in green tea.
proanthocyanidins – The same benefit touted in grapeseed extract, proanthocyanidins are found in efficacious amounts in the whole mangosteen fruit.
While scientific researchers are still working to demonstrate how these phytochemicals work together synergistically, the phytonutrients found in the whole fruit are among the most studied, touted and beneficial in existence today. This much is certain: extracts can never match the incredible spectrum of benefits available in the honored mangosteen fruit.


Benefits
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Dozens of studies demonstrate the incredibly beneficial properties of the mangosteen fruit. Among the most important benefits:

Sustains a healthy cardiovascular system*

The cardiovascular system (or circulatory system) includes the heart, the blood and blood vessels. The importance of maintaining a healthy cardiovascular system cannot be overstated. Because of poor diet and nutrition heart conditions are the number one cause of death and disability in the United States and most European countries.
Supports cartilage and joint function*

Cartilage is a dense connective tissue found in the joints, the rib cage, the ear and the nose. The knee joint, one of the most complex in the body, is more likely to be injured than is any other joint.
Strengthens the immune system*

Inflammation is one of the first responses of the immune system to infection. Symptoms will usually include a redness or swelling, both caused by an increase in blood flow.
Promotes a healthy seasonal respiratory system*

The respiratory tract is a common site for infections. Upper respiratory tract infections are one of the most common infections in the world, accounting for one billion illnesses in the United States annually.
Maintains intestinal health*

The gastrointestinal tract—consisting of the mouth, pharynx, esophagus, stomach and small and large intestines—is a prominent part of the immune system. Gastroenteritis is inflammation of the intestines and is the most common disease of the intestines.
Neutralizes free radicals*

Large molecules with powerful antioxidant properties, like xanthones, may stabilize free radicals. Left uncontrolled, free radicals can damage cells, tissue or DNA.
*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

State of the Mangosteen Category: 2008
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Aaron Garrity
CEO


The mangosteen is leading the race in superfruits and healthy foods, according to the 2008 Packaged Facts Food Flavours and Ingredients Outlook. XanGo LLC, the company that created the category when it introduced XanGo® Juice to a global market in 2003, continues to dominate the space, leading the category with more than 80 percent of market share*.

Setting scientific research standards

With scientific partners that include Northridge, Calif.-based Medicus Research, Weber State University and leading independent laboratories, XanGo is spearheading the scientific exploration of the whole mangosteen fruit through a tiered approach based on safety, standardization and efficacy.

As awareness and consumption of the mangosteen has increased worldwide, so has the need to better understand the fruit’s most prominent phytonutrient, xanthones. Through XanGo’s leadership, independent researchers have established a credible scientific method for testing and measuring xanthones.

Now, through this peer-reviewed, published study, category participants and consumers have a more consistent and reliable method of measuring and marketing mangosteen products relative to xanthone content claims.

A pre-clinical, preliminary 28-day study of XanGo Juice by Charles River Laboratories of Montreal identified the bioavailability of xanthones to determine how many xanthones are actually absorbed and the pathway they travel. Study director Susan McPherson, MSc, senior research scientist at Charles River Laboratories, said preliminary research findings demonstrate that the proprietary whole fruit formula in XanGo Juice leads to high levels of xanthone absorption.

Ongoing research shows high absorption of xanthones in defined dosages, with elements of the whole mangosteen fruit as a delivery vehicle. Unnaturally elevated levels of xanthone consumption actually were shown to result in decreased absorption efficiency.

Research shows artificially inflating or manipulating a product with xanthone extracts may not add any value. The mangosteen presents more value in its whole fruit form, as presented in XanGo Juice. There are many other phytochemicals found in the fruit that have beneficial effects, which are lost in extraction or jeopardized when the natural balance of the fruit is manipulated.

It’s better to respect the mangosteen as nature intended. And honor the true definition of “whole fruit” usage. If you say it, you should mean it. Whole fruit is a promise and consumers want that access to the mangosteen. In keeping that promise, XanGo launched the leading consumer resource for mangosteen science, www.thewholefruit.com.

Consumers deserve product innovation

In a new era of consumer demand for the mangosteen, millions around the world are looking for access to the astonishing mangosteen fruit in a variety of fresh product vehicles. Consumers everywhere are clamoring to make the mangosteen a part of their active and healthy lifestyles.

During the past year, XanGo expanded the global reach of the category through expanded access to our flagship product, XanGo® Juice to nearly one million distributors who operate now in more than 20 countries and territories.

Last spring, XanGo introduced XALO™ into European markets, where interest and sales have soared. XALO’s formula combines the acclaim of aloe with the mangosteen to offer consumers a combination of great taste and vibrant nutritional benefits in a complete and complex functional beverage. Through this proprietary blend of some of the world’s most celebrated botanicals, consumers may receive the following nutritional and antioxidant benefits: support of digestive health; revitalization and regeneration of healthy skin; improvement in proper absorption of vital nutrients; and a boost of natural energy levels.

In January, XanGo launched the XanGo Single, a one-ounce single-serving package of XanGo Juice allowing consumers the ease of carrying their recommended daily serving with them throughout the day.

New research shows the effectiveness of the mangosteen and xanthones in skin health and nutrition. Performance from mangosteen properties proved effective in improving age-related changes in the skin as well as enhancement of skin texture and touch. Another study demonstrated the mangosteen’s antioxidant punch in taking on acne-producing bacteria.

Later this year XanGo will launch a product line Glimpse, Intuitive Skin Care. GLIMPSE by XanGo is built to respond to specific skin care needs with an intelligent xanthone formulation that puts the green power of the earth at your service. GLIMPSE will feature a revolutionary, patented xanthone formulation that only XanGo can create. XanGo developed our exclusive xanthone formula for GLIMPSE through scientific exploration and advanced skin nutrition technology. Keep watch for more news on Glimpse at www.XanGoLaunch2008.com.

A new marketing revolution

Education and dialogue have been key components in XanGo’s creation and advancement of the mangosteen supplement category worldwide. In October 2007, XanGo introduced XanGo.TV the first brand-centric video sharing site at this level in the marketplace.

XanGo.TV is a big hit with over a million visitors already. Distributors and consumers worldwide are producing, sending and sharing XanGo.TV videos about their experiences with the mangosteen and XanGo Juice. XanGo.TV is dedicated to broadcasting the XanGo lifestyle by providing visitors an inside view of real-life stories and insights. With a library of videos and podcasts, visitors can chronicle the genesis of the mangosteen supplement category creator as it evolves to a surging global market.

In 2008, XanGo hosted its inaugural XanGo.TV Awards Show, recognizing the best video entries from distributors around the world. The Top 10 winners from among more than 200 entries and from more than 20 international markets who put their XanGo stories and inspirations into short films were honored during a 20-minute online broadcast event at www.xango.tv.

XanGo is intent on continuing to lead the market as the worldwide leader in mangosteen-based products. Supported by the success of the direct sales model, XanGo is one of the world’s fastest growing companies and will continue to set high goals for its corporate innovation and charitable work.

Why Whole Fruit
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Mike Pugh
Sr. Manager of R&D



I have been asked many times why we use whole fruit and not extracts and concentrates. This question has been asked repeatedly during my 16 years in the industry. I have heard arguments from how the whole plant has the essence of Mother Nature to how we do peer reviewed double blind studies on multiple active compounds. As I have listened to these arguments, I have come to some conclusions. I would like to share a few of them with you.

At the beginning, I also thought that all plants had a few active ingredients and that standardizing and concentrating those ingredients made them better and easier to study. It was just too difficult to study a plant that had hundreds or thousands of chemicals and thus be able to control all of the variables. That is true. Today’s method of testing and validating physiological activity is done with isolating active components from a medicinal plant that contains numerous active compounds. This method has saved millions of lives and has improved the quality of life for many. As we see with present drug treatments, though, we find that we have a lot more side effects when we concentrate and isolate. What we miss today is the possibility of synergetic and antagonist activity that comes from whole foods. We miss the fact that a little of a lot of things over a long period of time is better than having to treat with one chemical in large doses over a short period of time.

I was reading a paper by Kevin Spelman where he nailed what I have been thinking for a long time. He presented at a conference in Montreal, talking about how we influence the environment but also how the environment influences us. As we influence the environment or plants they, in turn, change. We then consume those plants and our bodies change to survive. I really enjoyed how he interwove everything together and made everything interdependent on each other. This communication between organism and environment is called chemistry. In our early diets, humans consumed between 80-220 plants and thus were exposed to a very high number of phytochemicals in the range of 8,000-22,000 (and quite likely higher). In our modern diet, we consume about 10,000 compounds including pesticides but, compared to the hunter/gather nature of our ancestors, we have seen a reduction in our consumption of phytochemicals.

Why is this important? Our bodies are designed to consume thousands of chemicals in low dosages. In our present diets, we consume lesser amounts of phytochemicals in higher concentrations. We have developed a detoxification route in our bodies called P450 enzymes. These enzymes are able to detoxify our bodies from harmful substances and they are also able to change inert substances into helpful chemicals in our body. P450 enzymes have the ability to evolve rapidly. Genes allow animals to generate a metabolic resistance to plant compounds that are designed to dissuade grazers and also allow plants to generate new compounds to deter herbivory. Plants and animals have inherit processes that allow them to adapt to their environment and use what makes them stronger and inhibit what makes them weaker. P450 in plants and animals have been engaged in the cyclical process of dissuading each other and helping each other when it fit. Over time, this relationship has developed into a real partnership. We have all seen now how plants and humans coexist. Take soybeans, for example. They have much to offer humankind and are cultivated and used as food around the world. Where they are consumed in moderate amounts, they seem to show lower levels of estrogenic disease. Also flavonoids are huge in the plant kingdom. We have seen in the world where daily consumption of green tea can lead to lower levels of disease, like heart disease and cancer. In Asia, large fields are dedicated to the growing of soybeans and green tea. Green tea and soy beans are much more abundant with the human partnership than if they had grown in the wild—humans are much healthier with these plants at their disposal than if the had to wild craft them. Is there a relationship? I think so.

As we have broken down the mangosteen fruit and looked at its individual chemical components, we have seen hundreds if not thousands of phytochemicals in specific quantities. In fact, some of the chemicals have not yet been identified nor do we know what synergistic or antagonistic effects they have. We have also noticed physiological changes in some of the actives when they are separated and then added back to the whole fruit. Are we ready to say that xanthones are the only active? Are we ready to say that xanthones separated from the whole fruit are better? Do we understand the plant so well; we can pick and choose which phytochemicals to keep and which ones we don’t need? I would say no.

We are now seeing drug research start to target multiple substances on multiple sites. We have also seen research where they combine multiple drug and nutritional items at lower dosages and have better outcomes with fewer side effects. For example, Wald and Law combine six drugs all below their standard dose. Those drugs are baby aspirin, three blood pressure drugs, a statin and folic acid. It extended life by 11 years with little or no side effects. What scientists are finding is that there is a matrix of pathways that different chemicals use. They work well together when delivered as nature intended. Whole plants seem to have more activity and fewer side effects when they are left in their own state. Kevin Spelman quotes saying, “Nature’s mixtures seem to function with broad specificity and low affinity. This phytochemical economy, an efficient and broad spectrum ensembles of constituents, would not likely act on just one target, but on multiple targets, functionally converging on biochemical pathways. Thus, phytochemical matrices, with their ensemble properties tripping multiple targets, may provide an enhanced pharmacological efficiency as compared to isolated compounds. Moreover, the use of phytomedicines, as compared to isolated chemicals, may offer a safer clinical strategy in the treatment of many diseases.” I could not say it better.

To end this blog, I want to quote one more paper from the American Journal of Clinical Nutrition, which states: “We believe that the evidence suggests that antioxidants are best acquired through whole-food consumption, not as a pill or an extract.” Why do we use the whole fruit and not extracts and concentrates? I think the facts stand for themselves.

Setting a True Xanthone
Measurement Standard
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John Digles
Chief Marketing Officer



A big round of applause for our research team. Their new study, driven by Dr. Edward Walker of Weber State University and XanGo’s science whiz Mike Pugh, establishes a true scientific standard for measuring xanthones from the mangosteen fruit.

This research marks an important threshold for the worldwide mangosteen supplement category. Prior to this study, there was no single-lab validated standard for xanthone identification and measurement in the celebrated mangosteen fruit.

What makes this research so special? It’s credible science. While XanGo was the engine that powered the work, an independent team of respected researchers steered the process and determined the findings. The study utilized AOAC protocols. AOAC International is a not-for-profit scientific association that sets standard methods which allow consumers to have confidence in analytical results obtained from scientific analysis.

Dr. Walker’s xanthone measurement standard provides the industry with a duplicable, analytical method of testing. And it shows that true appreciation of the mangosteen—and its benefits—begins with the whole fruit, as nature intended.

This study was peer-reviewed by a panel of experts and published in the June 2007 Journal of Separation Science. The Natural Products Association recognized Dr. Walker, Mike Pugh and the research team with first place for this landmark research. Click here to read all about this science award.

XanGo congratulates the research team for this outstanding accomplishment. As category creator and marker leader, we are dedicated to leading the way with credible research of the complete mangosteen fruit. This award-winning research ensures more consistent and reliable marketing of mangosteen products to consumers relative to claims of xanthone content.


Welcome
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Justin Banner
VP, Corporate Strategy



Welcome to thewholefruit.com, your online resource to exploration of the whole mangosteen fruit.

XanGo Juice gives the world access to the benefits and taste of the mangosteen through a proprietary whole fruit formula. XanGo’s respect of the whole fruit and usage of the entire mangosteen - pulp, rind and seeds - led to the company’s creation of one of the world’s fastest growing dietary supplement categories. And one of the hottest natural products in the marketplace.

thewholefruit.com is a science and research-driven site. It’s a valuable tool to understanding the power of the complete mangosteen. Here we will analyze credible research into the mangosteen fruit and provide you with breaking scientific news on the mangosteen and its nutritional assets.

XanGo’s proprietary formula for XanGo Juice is based on a puree of the whole mangosteen fruit. Research shows the mangosteen, in its whole fruit form, is home to an impressive roster of xanthones, catechins and proanthocyinidins.

Science tells us the key to getting the full benefit of the mangosteen fruit is to have access to the whole fruit. Separating parts of the fruit detracts from its value. Adding powders or extracts in an attempt to increase value jeopardizes the mangosteen’s natural balance and diminishes its power.

Our Science Gallery on this site provides a history of the mangosteen and the decades of study on this coveted fruit. Check out our Benefits page for the research-supported structure function claims relating to usage of the whole fruit. From sustaining a healthy cardiovascular system to joint and cartilage support and a stronger immune system, the mangosteen is a fascinating botanical.

We look forward to advancing the research on the mangosteen.

This value of meaning what you say is an important one for our business. There’s an inherent responsibility in marketing a natural product. Those who distribute and consume dietary supplements are seeking a benefit and they deserve to know what they are getting.

XanGo® Juice is recognized as a “whole fruit” dietary supplement. We say whole fruit. And we mean it.

When we created XanGo Juice - and a new dietary supplement category - we developed a propriety whole fruit formula designed to give the world the great taste and benefits of the entire mangosteen fruit.

Our proprietary formula for XanGo Juice begins with a puree of the whole mangosteen fruit from the best farms. XanGo sources and purees the whole fresh mangosteen — pulp, rind and seeds - so you can receive the benefits of the fruit as nature intended.

The mangosteen is nature’s most concentrated source of xanthones. Research shows the mangosteen’s xanthones are centralized in the rind or pericarp, the outer skin of the fruit. In addition to xanthones, the mangosteen is rich in flavonoids, catechins and proanthocyanidins.

XanGo Juice delivers the full benefit of some 40 xanthones as well as the advantage of other powerful nutrients through true usage of the whole fruit.

Many products within our category use powders, extracts or select parts from the mangosteen and claim to deliver “the whole fruit.” This claim can be misleading to consumers in pursuit of mangosteen nutrients and benefits.

Some mangosteen products use only the pulp, the inner part of the fruit. The use of the pulp and exclusion of the rind where most of the xanthones reside is not the “whole fruit.”

The use of extracts of the mangosteen and the use of powders in an attempt to add xanthones or other elements can actually lead to a reduction of the fruit’s natural nutritional value. By definition, extract clearly does not mean “whole fruit.”

Those who want to market this amazing fruit should recognize nature’s perfection. We can’t make the mangosteen better by taking it apart.

Manufacturers who aim to be part of this exciting category have a right to make their mangosteen products their way. And consumers in pursuit of the mangosteen’s health benefits have a right to know the truth.




Mangosteen


For centuries, the varied cultures and societies of Southeast Asia have revered the mangosteen. Although the mangosteen has been touted for its splendid flavor, it has also been suggested that use of the whole mangosteen fruit can promote good health. In fact, the whole mangosteen fruit—especially the xanthone-packed rind—has also been utilized in folk medicine to treat a variety of health conditions. As early as 600 AD, scribes in Southeast Asia recorded the use of the mangosteen as a general remedy and healing agent.



Mangosteen: "The Queen of Fruits"
The early benefits of the mangosteen are both broad and convincing. Legend even has it that Queen Victoria offered knighthood to any subject who could bring her a mangosteen fruit in prime condition. Sadly, no one succeeded in delivering the mangosteen. According to the legend, the virtual impossibility of preserving the fruit during the weeks-long journey prohibited anyone outside of the growing regions from enjoying the sensational flavor of the mangosteen. But, some have suggested that thanks to the Queen’s admirable quest, the fruit achieved the heralded title, “Queen of Fruits,” a name still used by mangosteen adorers around the globe.



Discovering Mangosteen: Joe's Story
The story of XanGo is straight and simple—It starts with one man and a café, and ends…well, it doesn’t end. And that’s the best part of the story.

Joe Morton knew something was out there, something that would change the nutritional supplement landscape. He kept his eyes open; he scoured street markets and rural gardens. He had seen groundbreaking products before—aloe vera, cayenne, echinacea—and realized that the next revolution was just around the corner. And, as he sat in an open-air café in Southeast Asia, Joe found what he’d been looking for. Only it wasn’t quite what he expected. The waiter delivered a fruit unlike any other, the revered and celebrated mangosteen fruit. The flavor was initially and completely sensational. Sweet, yet not overwhelming. Smooth, yet consistently intriguing. It defied description and invited inspection. His interest piqued, Joe asked questions. And answers arrived in piles. The mangosteen was a dual-powered wonder, a fusion of fantastic flavor and health-promoting benefits. Almost sleeplessly attracted to its rare power, Joe immediately recognized the potential of the practically unknown mangosteen fruit. Fueled by the desire to share the mangosteen with the world, Joe dug deeper. He enlisted the research skills of medical professionals. And found stacks of supporting research. The findings even outpaced Joe’s eternal optimism. And, with decades of research and studies, Joe knew that it was time for the world to learn about the Queen of Fruits, the mangosteen.



From Mangosteen to XanGo
XanGo (derived from the words XANthones and manGOsteen) is the first, the original mangosteen supplement, a true category creator. Today, Joe Morton’s vision has been confirmed. Existing mangosteen research has been validated with thousands of individual accounts in dozens of countries. The whole-fruit formula of XanGo® Juice delivers a host of essential and complementary nutrients, including the potent antioxidant properties of xanthones—a vigorous family of phytonutrients found abundantly in the rind of the mangosteen fruit.







Mangosteen Tree



While the name hints at the well-known mango, the mangosteen tree should not be confused with that plant or fruit. The mangosteen tree is actually in the same plant family as St. John's Wort, a recognized herbal supplement.

The tree that bears the mangosteen is as unique as is its fruit. It grows 20 to 80 feet tall. Its bark is a dark brown (nearly black) color, except when and where it’s bleeding yellow latex. It has short, thick and leathery evergreen leaves. The fruit of the mangosteen tree must be harvested by hand. 12" wide flowers grow in clusters of 3-9 at its branch tips. It takes two or more years for the tree to reach 12" in height. It is widely believed that the mangosteen trees originated in the islands of Sunda and Molucca (in the East Indies). The first fruit harvest may take place 7-9 years after planting, but most take place in the first 10-20. The average yield of full-grown trees is 500, but some trees yield as many as 5,000 ripe mangosteens. Some trees provide fruit up to 100 years. The mangosteen tree is "ultra-tropical" and can't tolerate temperatures below 40°F or above 100°F. All attempts to grow the trees in locations north of 20° latitude have failed.






Mangosteen Fruit


The mangosteen fruit consists of a deep purplish rind, a succulent white pulp (four to eight segments), and between one and five seeds. The mangosteen fruit rind, while typically bitter, contains xanthones and other compounds that demonstrate impressive health benefits. The pulp, on the other hand, is pure taste-bud bliss—a sensational flavor unlike any other.

"The mangosteen outranks in delicacy, if not all other fruits in the world, certainly all others of the tropical zone. I admit it is a joy to the eye as well as to the palate to feast on mangosteens." —David Fairchild, PhD., agricultural explorer, botanist and author.



Mangosteen Fruit Facts
To select the best table fruit, choose the mangosteen with the highest number of stigma lobes at the apex (the "bottom" of the fruit). This fruit will have the highest number of fleshy segments and the fewest seeds.
Each serving of mangosteen contains up to 5 grams of fiber.

The entire fruit is typically 1-3" in diameter—roughly the size of a tangerine.
The rind (or skin) of the mangosteen is 1/4-3/8" thick and contains a purplish pigment that has been used as a dye.
Fully developed seeds lose viability just 5 days after removal from the fruit.
Some people boil, roast, and eat the mangosteen seeds—which are also believed to contain unique properties.






Mangosteen Juice


After harvest, mangosteen fruit undergoes a proprietary process that washes and softens the rind; at the same time, pre-ship mangosteen samples are tested and approved before the harvest is accepted and prepared for the production process. Fruit that meets strict quality guidelines is then submitted to a three-stage purée process to preserve flavor and nutritional integrity, and create the Queen of mangosteen juices from the Queen of Fruits. To meet impressive demand and secure a fresh final product, XanGo® Juice is formulated and manufactured daily.


Mangosteen Juice Supplement Standards
The premium standard of XanGo's mangosteen juice supplement is guaranteed through a number of quality controls, including:

Definition and analysis of every processing step.
HACCP system to find and keep quality in every part of the process.
Implementation of CGMP (Current Good Manufacturing Practices).
FDA and USDA audits.
Hundreds of quality control tests, checks, balances, controls and processes—from orchard to order.
ISO certification of WILD Flavors, a partner in the formulation of XanGo's premium mangosteen juice supplement—XanGo® Juice.

XanGo's Mangosteen Juice Supplement
When XanGo Juice arrives at its destination, every consumer is guaranteed the same incredible experience—unmatched flavor and premium nutritional support. The final product boasts:

The nutritional attributes of the whole mangosteen fruit. In fact, our mangosteen juice supplement is the only product on the market the utilizes the entire mangosteen fruit.
A bio-available form superior to capsules or tablets.
A category-creating, market-leading, premium dietary supplement.
A flavorful experience unlike any other.
The harnessed power of xanthones—one of the mangosteen’s powerful, biologically active components.
Decades of promising research and continuing health revelations.
A supplement that is safe for everyone.




Xanthones


Among the powerful phytonutrients found in the rind of the mangosteen, xanthones stand alone in their impressive benefits. Scientific studies suggest xanthones may promote healthy bodily function. The whole mangosteen fruit, packed with naturally occurring xanthones, may help:

maintain intestinal health*
strengthen the immune system*
neutralize free radicals*
support cartilage and joint function*
promote a healthy seasonal respiratory system*

Xanthones in Mangosteen
Researchers have identified dozens of biologically active xanthones in the mangosteen fruit. Today, researchers are just beginning to uncover the powerful scientific properties behind the mangosteen fruit.


What are Xanthones?
Xanthones are:

A unique class of biologically active compounds possessing numerous bioactive capabilities—such as antioxidant properties.


A restricted group of plant polyphenols, biosynthetically related to the flavonoids.
o polyphenol – a group of plant chemical substances characterized by the presence of more than one phenolic group. Polyphenols are responsible for the color of some plants and are considered strong antioxidants with potential health benefits.
o flavonoid – over 5,000 naturally occurring flavonoids have been characterized from various plants. The beneficial effects of plant-derived food are often attributed to flavonoid compounds—rather than known nutrients—as they show a wide range of biological effects.


Chemically speaking, planar-six carbon molecules in a conjugated ring system consisting of a backbone molecule and various chemical groups attached to it. The backbone consists of two benzene rings bridged through a carbonyl group and oxygen. Each ring is connected in a fused formation not allowing free rotation about the carbon-carbon bonds. This unique backbone along with type and position of the attached chemical groups define specific functionalities (properties) of xanthones.







Phytonutrients


Derived from the Greek word phyto (plant) and nutrient (a constituent of food necessary for normal physiological function), phytonutrients—also known as phytochemicals—are natural, bioactive compounds found in plant foods. Most phytonutrients overlap and complement one another, boasting complete benefits that include antioxidant effects and immune system stimulation. In short, specific phytonutrients found in fruits and vegetables work together with other nutrients to protect your health.

More than 900 different phytonutrients have been found in plant foods. And even more will be discovered in coming years. These protective plant compounds are an emerging area of health and nutrition, with new research reported almost daily.


Phytonutrients in XanGo® Juice
The careful crafting of XanGo’s all-natural, whole-fruit, mangosteen purée ensures that all of the impressive and healthful phytonutrients of the fruit enrich XanGo® Juice. The strongest and most researched phytonutrients of the mangosteen are its xanthones.






Antioxidants


The whole mangosteen fruit has been shown to contain powerful antioxidants—compounds that inhibit oxidation or reactions promoted by oxygen and peroxides. Antioxidants are highly regarded for their ability to protect the body from the deteriorating effects of free radicals.



Free Radicals
Omni-present in our food, air and environment, free radicals storm our bodies every day. It’s a simple fact. Free radicals (compounds that seek an electron in order to become atomically balanced) attack our cells, stealing electrons from any substance with which it comes in contact. By removing electrons from healthy compounds, free radicals inflict damage—often known as oxidation—which is irreversible.



Antioxidants Can Help
The good news—antioxidants, like the ones abundant in every mangosteen, preempt free-radical damage by donating the needed electron and balancing the substance, rendering the free radical harmless.




Sensory Overload

In the palm of your hand, it’s the size of a tangerine. Deep purple rind. Squeeze it and the split is perfectly symmetrical, exposing the glistening white pulp. Bursting with xanthones, benefits abound. The fruit dances with flavor as it reaches your tongue. Your tastebuds celebrate. Sweet, crisp and cool—XanGo® Juice is delicious and dreamy. Bold, yet refined. This sultry beverage is truly one of a kind. Achieved through a proprietary formula that purées the fruit and the rind. Taste the sensational goodness of the Queen of Fruits.



Garcinia Mangostana


The mangosteen fruit is known in the scientific/botanical world as Garcinia Mangostana L.—named after the French priest and explorer Laurentiers Garcin who studied and diagramed the mangosteen in 1693.


Other Names for Garcinia Mangostana
The mangosteen (Garcinia Mangostana) also answers to similar names in other communities. Heres a taste of the language and location variations:

Spanish—mangostán, mangostín
French—mangoustan, mangostanier, mangouste, mangostier
Indonesia—manggis
Philippines—manggustan, manggis
Cambodia—mongkhut
Laos—mangkhud
Thailand—mangkhut
Vietnam—cay mang cut
Portuguese—mangostao
Malaya—mesetor, semetah, sementah




References


12013
Matsumoto K, Akao Y, Kobayashi E, et al. Induction of aptosis by xanthones from mangosteen in human leukemia cell lines. J Nat Prod 2003;66:1124-7.
12014
Suksamrarn S, Suwannapoch N, Phakhodee W, et al. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chem Pharm Bull (Tokyo) 2003;51:857-9.
12015
Ho CK, Huang YL, Chen CC. Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines. Planta Med 2002;68:975-9.
12016
Nilar, Harrison LJ. Xanthones from the heartwood of Garcinia mangostana. Phytochemistry 2002;60:541-8.
12017
Chairungsrilerd N, Furukawa K, Ohta T, et al. Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med 1996;62:471-2.

XanGo is the 9th fastest growing company in US History. The top 10 include companies like Walmart, Starbucks, Dell Computers, Yahoo and Ebay.

Of the top 10 fastest growing companies, XanGo is the only one that is privately held and debt free. In its 4th year, XanGo was awarded the Ernst & Young Entrepreneur of the Year Award.

XanGo Annual Sales:
1st year: $43 million
2nd year: $125 million
3rd year: $350 million
4th year: $450 million

XanGo has just completed its 5th year in business and in that year generated $800 million dollars in sales with just one product. $400 million of that was paid out to its independent distributors in the form of weekly, monthly and quarterly bonuses. Some bonuses are based on identifying new wholesale customers/distributors. Other bonuses are based on volume. The way we build our team allows volume to accumulate for you, without any effort on your part. Of course, a little effort will take you that much further.

XanGo is consumable; our customers try it, experience benefits, and continue to drink it based on the cumulative results they are receiving. Because of this XanGo has a tremendously high customer retention
rate.

XanGo currently does business in 22 countries. It has been featured on Fox News, World Business News and the Today Show. XanGo has been written about in Time Magazine, Sports Illustrated and Readers Digest. Our product's main ingredient has been featured in the New York Times and the Wall Street Journal, Shape Magazine, Diet and Nutrition and most recently on The Oprah Winfrey Show.

XanGo just surpassed Coca-Cola in its charitable contributions to Operation Kids...a children's foundation that is dedicated to helping children in third world countries. Please visit www.XanGoGoodness.org to learn more if you like.


XanGo has the facts right in front of you, and you can't afford to pass up this opportunity!

Products:

XanGo Juice, 3sixty5, and "Glimpse" (11/08)

$35.00 one time distributor fee.

www.myxango.com/edithsperl

http://ESperl08.themangosteenrevolution.com